An agreement has been reached between the club and Kerr's management after the 30-year-old informed his teammates of his intention to hang up the boots days after West Coast’s final game of the year.
Selected by the Eagles in the 2000 national draft, Kerr made his debut in round one of the following season, lining up for 19 games and winning the club’s Rookie of the Year Award, as well as a NAB Rising Star nomination.
A veteran of 220 games and polling second in the Brownlow Medal count in 2005, Kerr has played in two grand finals, winning the 2006 premiership.
Kerr was runner-up Club Champion in 2002 and represented his country at the International Rules Series that same year, earning All-Australian honours in 2007.
For a snapshot of Daniel Kerr's career in pictures, click here.
Injuries have cruelled the midfielder's output in recent years and he managed just 10 games in 2013, sidelined with knee issues which no doubt influenced his decision to end his career.
Football operations manager Craig Vozzo said Kerr had distinguished himself throughout his service to the West Coast Eagles.
"Daniel has been fortunate enough to achieve many accolades during his career and we take great pride in the football he had been able to produce over the past 13 years," Vozzo said.
"He has been an elite midfielder of the competition and set a high standard for his younger teammates to live up to.
“Daniel has been a terrific servant of this club and his skill and courage will be sorely missed, but always remembered by the club and our supporters.”
Kerr said the decision to retire had been a difficult one.
"I've been lucky to be able to wake up every day and do what I love, but lately it has become harder to get my body to carry out my mind’s instructions," Kerr said.
"It was hard to come to terms with the fact that I probably wasn't going to be able to play to the standard that I wanted, but I recognise that my best football is past me and it's time to step aside to let the new generation through.
"I've had the time of my life at this football club and I've made friends that I'll keep until the end of my days."